CAMPTOTHECIN AND KHAT (CATHA EDULIS FORSK.) INDUCED DISTINCT CELL DEATH PHENOTYPES INVOLVING MODULATION OF C-FLIPL, MCL-1, PROCASPASE-8 AND MITOCHONDRIAL FUNCTION IN ACUTE MYELOID LEUKEMIA CELL LINES

Abstract Background An organic extract of the recreational herb khat (Catha edulis Forsk.) triggers cell death in various leukemia cell lines in vitro.The chemotherapeutics camptothecin, a plant alkaloid topoisomerase I inhibitor, was tested side-by-side with khat in a panel of acute myeloid leukemia cell lines to elucidate mechanisms of toxicity.R

Prior to the acquired immune deficiency syndrome (AIDS) epidemic, more than 50% of 6KG the new hepatitis B virus infections in the United States and Canada were sexually transmitted, approximately one-quarter by heterosexual men and women and one-third by homosexual men.The percentage of hepatitis B virus infections attributable to heterosexual tra

In the sacred religion of Islam, Living prescribed punishment has great position.One of the prescribed punishments is related to theft that is explicitly is mentioned in The Holy Quran (Maeda, 5, 38).The execution of prescribed punishment for theft is subject to the existence of all conditions together.One of which is the case when the stolen prope

The author explores the evolution, functioning, similarities and differences between the original Bretton Woods international monetary system that operated from 1945 to 1973 and the present modified institution, which is symbolically called Bretton Woods 2 System.The existing international financial architecture keeps on being based on the hegemony